抗氧化剂（维生素C、E和姜黄提取物）对甲巯咪唑诱导的大鼠甲状腺功能减退的影响。

Effect of antioxidants (vitamin C, E and turmeric extract) on methimazole induced hypothyroidism in rats.

作者信息

Deshpande Usha R, Joseph Lebana J, Patwardhan Uma N, Samuel Aban M

机构信息

Radiation Medicine Centre (BARC), C/o Tata Memorial Centre Annexe, Parel, Mumbai 400 012, India.

出版信息

Indian J Exp Biol. 2002 Jun;40(6):735-8.

PMID:12587721

Abstract

The study was to investigate the protective effect of antioxidants against methimazole (MMI) induced hypothyroidism in rats. Male Wistar rats were fed MMI, MMI plus vitamin C, MMI plus vitamin E and MMI plus turmeric extract (TE) supplemented diet. At the end of the experiments, thyroid weights, thyroxine (T4), triiodothyronine (T3) and cholesterol levels were determined. It was observed that MMI treated rats showed increase in thyroid weights, very low levels of circulating T4, T3 and increased levels of total cholesterol as compared to controls (P< 0.001). However, rats which received Vit. C, Vit. E or TE along with MMI showed reduced weights (38-55% less) in thyroid glands (P < 0.01), less suppressed T4 and T3 levels (2-6% and 7-35% respectively) and less increase in total cholesterol levels (19-52%) which are statistically significant. The data suggest the positive effect of antioxidants on thyroid gland which could be due to direct involvement of antioxidants on thyroid gland.

摘要

该研究旨在探讨抗氧化剂对甲巯咪唑（MMI）诱导的大鼠甲状腺功能减退的保护作用。将雄性Wistar大鼠分为四组，分别给予含MMI、MMI加维生素C、MMI加维生素E以及MMI加姜黄提取物（TE）的饲料。实验结束时，测定大鼠的甲状腺重量、甲状腺素（T4）、三碘甲状腺原氨酸（T3）和胆固醇水平。结果发现，与对照组相比，接受MMI治疗的大鼠甲状腺重量增加，循环T4、T3水平极低，总胆固醇水平升高（P<0.001）。然而，同时接受维生素C、维生素E或TE与MMI的大鼠甲状腺重量减轻（减少38-55%）（P<0.01），T4和T3水平受抑制程度较低（分别为2-6%和7-35%），总胆固醇水平升高幅度较小（19-52%），且具有统计学意义。数据表明抗氧化剂对甲状腺具有积极作用，这可能是由于抗氧化剂直接作用于甲状腺所致。