Braunwald E, Maroko P R
Am J Cardiol. 1976 Mar 31;37(4):550-6. doi: 10.1016/0002-9149(76)90395-7.
In anesthetized open chest dogs, hydrocortisone (50 mg/kg body weight administered 30 minutes after occlusion and 25 mg/kg 12 hours later) substantially reduced the size of myocardial infarcts, as reflected by both myocardial creatine phosphokinase activity and histologic appearance 24 hours later. Similarly, hyaluronidase, which increases diffusion through the extracellular space and presumably facilitates delivery of substrate to ischemic cells, also reduced the extent of myocardial necrosis after coronary occlusion in the dog. In view of the salutary effects of hyaluronidase and the absence of serious side effects, this agent was administered clinically to two groups of patients, who were compared with two groups of untreated control subjects. Hyaluronidase (500 National Formulary units/kg X 8) was shown to result in a significantly more rapid reduction in the magnitude and the extent of precordial S-T segment elevations, and in patients treated within 4 hours a tendency to a lower incidence rate of Q waves and a smaller reduction of R waves.
在麻醉开胸犬中，氢化可的松（闭塞后30分钟给予50mg/kg体重，12小时后给予25mg/kg）显著减小了心肌梗死面积，这在24小时后的心肌肌酸磷酸激酶活性和组织学表现中均有体现。同样，透明质酸酶可增加细胞外间隙的扩散，并可能促进底物向缺血细胞的传递，它也减少了犬冠状动脉闭塞后心肌坏死的范围。鉴于透明质酸酶的有益作用且无严重副作用，该药物被临床应用于两组患者，并与两组未治疗的对照受试者进行比较。结果显示，透明质酸酶（500美国国家处方集单位/kg×8）能使胸前区S-T段抬高的幅度和范围显著更快地降低，并且在4小时内接受治疗的患者中，出现Q波的发生率有降低趋势，R波降低幅度较小。
