Most A S, Capone R J, Mastrofrancesco P A
Am J Cardiol. 1976 Jul;38(1):28-33. doi: 10.1016/0002-9149(76)90058-8.
The effect of hyaluronidase on the early course of acute myocardial infarction was evaluated in closed chest anesthetized pigs. One hour after balloon catheter occlusion of the left anterior descending coronary artery, hyaluronidase (500 units/kg body weight) was rapidly infused in 10 animals while 9 received no treatment. The animals were than observed over the next 4 hours. Cardiac output, heart rate, mean arterial pressure and left atrial pressure were not significantly affected by treatment. Heart rate increased and arterial pressure decreased in each group to a comparable degree of 5 hours, but left atrial pressure and cardiac output were unaffected. Precordial S-T segment mapping revealed no significant difference between the two groups. S-T segments rose to a comparable degree in each group and peaked before 1 hour. Hyaluronidase had no acute effects on the S-T segment map in the first 30 minutes after infusion or during the subsequent return of the map toward control level. Slightly lower S-T segments in the hyaluronidase-treated group at 5 hours was of borderline significance but was attributed to factors other than the drug intervention. Changes in ventricular wall motion were assessed angiographically, and all animals manifested akinetic or dyskinetic segments. A significant reduction in shortening fraction of involved segments was seen after occlusion, but no difference was observed between the two groups at 5 hours. Shortening fraction of the combined anterior and anteropical segments decreased from 66 +/- 10 to 20 +/- 6 percent at 5 hours in the hyaluronidase group (no. = 7) whereas in the control group (no. = 6) it decreased from 68 +/- 6 to 28 +/- 9 percent. Comparable increases in end-diastolic volume were also present at 5 hours in each group. Volumes increased from 80.6 +/- 5.1 to 97.5 +/- 6.4 ml3 at 5 hours (P less than 0.05) in the hyaluronidase-treated group (no. = 10) compared with 86.9 +/- 8.9 to 104.8 +/- 11.0 ml3 (P less than 0.05) in the control group (no. = 8). Hyaluronidase did not alter the early course of acute myocardial infarction in pigs. Species differences may contribute to different results reported to date.
在闭胸麻醉猪身上评估了透明质酸酶对急性心肌梗死早期病程的影响。在通过球囊导管闭塞左前降支冠状动脉1小时后，对10只动物快速输注透明质酸酶（500单位/千克体重），而9只动物未接受治疗。随后在接下来的4小时内对这些动物进行观察。治疗对心输出量、心率、平均动脉压和左心房压无显著影响。每组动物的心率在5小时时均升高，动脉压均下降，且下降程度相当，但左心房压和心输出量未受影响。心前区S-T段标测显示两组之间无显著差异。每组S-T段均升高至相当程度，并在1小时前达到峰值。在输注后最初30分钟内或随后标测图恢复至对照水平的过程中，透明质酸酶对S-T段标测无急性影响。透明质酸酶治疗组在5小时时S-T段略低，具有临界显著性，但这归因于药物干预以外的因素。通过血管造影评估心室壁运动变化，所有动物均表现出运动减弱或运动障碍节段。闭塞后受累节段的缩短分数显著降低，但两组在5小时时未观察到差异。透明质酸酶组（n = 7）中，5小时时前壁和心尖前段联合节段的缩短分数从66±10%降至20±6%，而对照组（n = 6）中则从68±6%降至28±9%。每组在5小时时舒张末期容积也有类似增加。透明质酸酶治疗组（n = 10）中，5小时时容积从80.6±5.1 ml³增加至97.5±6.4 ml³（P < 0.05），而对照组（n = 8）中从86.9±8.9 ml³增加至104.8±11.0 ml³（P < 0.05）。透明质酸酶未改变猪急性心肌梗死的早期病程。物种差异可能导致了迄今报道的不同结果。
