Gulliani G L, Hyun B H, Litten M B
Am J Clin Pathol. 1976 Mar;65(3):390-6. doi: 10.1093/ajcp/65.3.390.
The applicability of blood recalcification time as a laboratory test to assess and thereby regulate heparin anticoagulation was evaluated. Normal values for blood recalcification time ranged from 65 to 135 seconds, with a mean and standard deviation of 99 and 12 seconds, respectively. Duplicate determinations showed a mean variation of 5%. Blood recalcification times increased as a linear function of increasing heparin concentrations in vitro. Comparison with whole-blood clotting times revealed reasonably good correlation between the two tests. For whole-blood clotting times of 20 to 45 minutes the corresponding blood recalcification times were 142 to 212 seconds. The therapeutic range is often considered to be twice the normal range (130-270 seconds). In-vivo study revealed the peak blood recalcification time in the first sample collected 30 minutes after heparin injection, and a progressive decline thereafter to the pre-injection level during the subsequent 4 hours. The blood recalcification time is a simple, precise and clinically useful test to monitor heparin therapy.
对血液复钙时间作为一种实验室检测方法来评估并进而调节肝素抗凝作用的适用性进行了评估。血液复钙时间的正常范围为65至135秒，平均值和标准差分别为99秒和12秒。重复测定显示平均变异为5%。在体外，血液复钙时间随肝素浓度增加呈线性增加。与全血凝固时间比较显示，这两种检测方法之间有较好的相关性。对于20至45分钟的全血凝固时间，相应的血液复钙时间为142至212秒。治疗范围通常认为是正常范围的两倍（130 - 270秒）。体内研究显示，在注射肝素后30分钟采集的第一份样本中血液复钙时间达到峰值，此后在随后4小时内逐渐下降至注射前水平。血液复钙时间是监测肝素治疗的一种简单、精确且临床上有用的检测方法。
