Levesque G, Samama M, Kher A, Barbier P, Horellou M H, Conard J
Haemostasis. 1981;10(2):97-103. doi: 10.1159/000214392.
The laboratory control of low-dose heparin therapy is generally regarded as unnecessary. A laboratory study of the effects of low-dose heparin was performed using different methods: an amidolytic method and a method involving the inhibition of factor Xa in a coagulation test. Variations in partial thromboplastin time, recalcification clotting time, thrombin time and the plasma antithrombin III levels were also studied. These tests were repeated (days 0, 1, 3, 8) in 27 women between the ages of 27 and 62 years who were undergoing gynecological surgery. They received 5,000 IU of heparin either twice or thrice daily. There was no correlation between heparin levels in the blood and global clotting tests simultaneously performed. The plasma heparin levels varied between 0 and 0.15 IU/ml with both methods. A detectable heparin concentration on days 1, 3 and 8 was present in only half of the cases receiving the twice daily regimen. The plasma antithrombin III activity and concentration were not modified during treatment.
低剂量肝素治疗的实验室监测通常被认为没有必要。使用不同方法进行了一项关于低剂量肝素作用的实验室研究：一种酰胺水解法和一种在凝血试验中涉及抑制因子Xa的方法。还研究了部分凝血活酶时间、复钙凝血时间、凝血酶时间和血浆抗凝血酶III水平的变化。对27名年龄在27至62岁之间接受妇科手术的女性重复进行了这些测试（第0、1、3、8天）。她们每天接受两次或三次5000国际单位的肝素。同时进行的血液中肝素水平与整体凝血试验之间没有相关性。两种方法测得的血浆肝素水平在0至0.15国际单位/毫升之间变化。在接受每日两次给药方案的病例中，只有一半在第1、3和8天能检测到肝素浓度。治疗期间血浆抗凝血酶III活性和浓度未发生改变。
