Chang H Y, Pandolfino J E, Shi G, Boeckxstaens G E, Joehl R J, Kahrilas P J
Northwestern University, Feinberg School of Medicine, Chicago, IL 60611-3008, USA.
Neurogastroenterol Motil. 2003 Feb;15(1):3-8. doi: 10.1046/j.1365-2982.2003.00386.x.
This study aimed to determine the effect of glucagon-induced gastric relaxation on the frequency of transient lower oesophageal sphincter relaxations (TLOSRs). Eight normal subjects (four male, age 18-52 y) were studied after a 6-h fast using a combined manometric barostat assembly. The recording was divided into two 1-h sessions: (1) a baseline period with the barostat set at minimal distending pressure (MDP) + 2 mmHg and (2) a period with continuous glucagon or placebo infusion with barostat set at MDP + 2 mmHg. Patients were studied on two different days and randomly received glucagon (4.8 microg kg(-1) bolus followed by 9.6 microg kg(-1) h(-1) infusion) on 1 day and placebo (saline) on another. Lower oesophageal sphincter (LOS) pressure, frequency of TLOSRs, and barostat bag volumes were determined for both placebo and glucagon infusion. Glucagon induced significant fundal relaxation compared with placebo (P < 0.05) and significantly decreased baseline LEOS pressure (P < 0.05). The frequency of TLOSRs was not altered by glucagon infusion compared with placebo. Despite causing substantial proximal stomach relaxation, glucagon did not increase TLOSR frequency. This suggests that the relevant gastric mechanoreceptors responsible for triggering TLOSRs do not respond to passive elongation.
本研究旨在确定胰高血糖素诱导的胃松弛对一过性下食管括约肌松弛（TLOSRs）频率的影响。8名正常受试者（4名男性，年龄18 - 52岁）在禁食6小时后，使用联合测压恒压器组件进行研究。记录分为两个1小时时段：（1）基线期，恒压器设置为最小扩张压力（MDP）+ 2 mmHg；（2）持续输注胰高血糖素或安慰剂的时段，恒压器设置为MDP + 2 mmHg。患者在两天内进行研究，随机在一天接受胰高血糖素（4.8 μg kg⁻¹推注，随后9.6 μg kg⁻¹ h⁻¹输注），在另一天接受安慰剂（生理盐水）。测定安慰剂和胰高血糖素输注时的下食管括约肌（LOS）压力、TLOSRs频率和恒压器气囊容积。与安慰剂相比，胰高血糖素诱导了显著的胃底松弛（P < 0.05），并显著降低了基线LEOS压力（P < 0.05）。与安慰剂相比，胰高血糖素输注未改变TLOSRs频率。尽管胰高血糖素引起了近端胃的显著松弛，但并未增加TLOSR频率。这表明负责触发TLOSRs的相关胃机械感受器对被动伸展无反应。
