Joyner L R, Massaro G D, Massaro D
Am J Physiol. 1976 Feb;230(2):295-7. doi: 10.1152/ajplegacy.1976.230.2.295.
We studied the oxygen consumption (QO2) of lung slices and the ultrastructure of the pulmonary granular pneumocyte in rats whose level of circulating thyroxine was altered. Rats given thyroxine for 6 days (1.0 mg-kg-1-day-1) and sacrificed on the 7th day had a serum thyroxine level of 18.9 +/- 2.7 mug/100 ml (mean +/- SD); rats given diluent alone for 6 days had a serum thyroxine level of 4.67 +/- 0.53 mug/100 ml. Rats subjected to a sham thyroidectomy has a serum thyroxine level of 7.27 +/- 1.47 mug/100 ml, whereas rats subjected to thyroidectomy had a serum thyroxine level of 1.13 +/- 0.55 mug/100 ml when sacrificed. The QO2 of lung slices from rats with high levels of circulating thyroxine was significantly greater than that of rats that received diluent alone. The QO2 of slices from rats whose thyroid glands were excised was significantly lower than the QO2 of slices from sham-operated rats. We did not find quantitative ultrastructural differences in granular pneumocyte mitochondria and lamellar bodies of rats given thyroxine compared to rats given diluent or between rats subjected to sham thyroidectomy compared to rats whose thyroid glands were removed.
我们研究了循环甲状腺素水平发生改变的大鼠肺切片的氧耗量（QO2）以及肺颗粒性肺细胞的超微结构。给予甲状腺素6天（1.0毫克/千克/天）并在第7天处死的大鼠，其血清甲状腺素水平为18.9±2.7微克/100毫升（平均值±标准差）；仅给予稀释剂6天的大鼠，其血清甲状腺素水平为4.67±0.53微克/100毫升。接受假甲状腺切除术的大鼠血清甲状腺素水平为7.27±1.47微克/100毫升，而接受甲状腺切除术的大鼠在处死时血清甲状腺素水平为1.13±0.55微克/100毫升。循环甲状腺素水平高的大鼠肺切片的QO2显著高于仅接受稀释剂的大鼠。甲状腺切除大鼠切片的QO2显著低于假手术大鼠切片的QO2。与给予稀释剂的大鼠相比，给予甲状腺素的大鼠颗粒性肺细胞线粒体和板层小体在超微结构上未发现定量差异；与甲状腺切除的大鼠相比，接受假甲状腺切除术的大鼠之间也未发现定量差异。
