Font M, Parellada E, Fernández-Egea E, Bernardo M, Lomeña F
Instituto Clínico de Psiquiatría y Psicología, Hospital Clínico y Universitario de Barcelona, España.
Actas Esp Psiquiatr. 2003 Jan-Feb;31(1):3-9.
The neurobiological bases underlying the generation of auditory hallucinations, a distressing and paradigmatic symptom of schizophrenia, are still unknown in spite of in-depth phenomenological descriptions. This work aims to make a critical review of the latest published literature in recent years, focusing on functional neuroimaging studies (PET, SPECT, fMRI) of auditory hallucinations. Thus, the studies are classified according to whether they are sensory activation, trait and state. The two main hypotheses proposed to explain the phenomenon, external speech vs. subvocal or inner speech, are also explained. Finally, the latest unitary theory as well as the limitations the studies published are commented on. The need to continue investigating in this field, that is still underdeveloped, is posed in order to understand better the etiopathogenesis of auditory hallucinations in schizophrenia.
尽管已有深入的现象学描述，但精神分裂症令人痛苦且具有代表性的症状——幻听产生的神经生物学基础仍不明确。这项工作旨在对近年来最新发表的文献进行批判性综述，重点关注幻听的功能神经影像学研究（正电子发射断层扫描、单光子发射计算机断层扫描、功能磁共振成像）。因此，这些研究根据其是否为感觉激活、特质和状态进行分类。还解释了为解释该现象而提出的两个主要假说，即外部言语与默读或内心言语。最后，对最新的统一理论以及已发表研究的局限性进行了评论。鉴于该领域仍未充分发展，为了更好地理解精神分裂症中幻听的病因发病机制，提出了继续在该领域进行研究的必要性。
