Reulbach Udo, Bleich Stefan, Maihofner Christian, Kornhuber Johannes, Sperling Wolfgang
Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen-Nuremberg, Germany.
Neuropsychobiology. 2007;55(2):89-95. doi: 10.1159/000103907. Epub 2007 Jun 15.
BACKGROUND/AIMS: Different neuroimaging techniques have indicated that auditory association and language cortices are active in patients with schizophrenia and auditory hallucinations. Auditory verbal hallucinations are thought to arise from a disorder of inner speech, but little is known about their origin.
Spontaneous magnetoencephalographic (MEG) measurements were recorded with a 74-channel two-sensor system (BIOMAGNES II) in 16 patients with schizophrenia and 8 healthy subjects in frequency ranges from 2 to 6 and 12.5 to 30 Hz. Eight patients had auditory hallucinations during the MEG recordings.
The total group of patients with schizophrenia showed a statistically significant elevation of the number of dipoles and dipole density maxima in slow frequency ranges compared to healthy subjects (p <0.001). Significant dipole activities in the fast frequency range were only found during auditory hallucinations (p <0.001). Dipole localization was concentrated in frontal and temporal regions depending on different qualities of hallucinations. In patients with external imperative voices we found a parallel activation of the dorsolateral frontal and temporal cortex.
We conclude that various auditory hallucinations in schizophrenia are induced by different neuronal activities and may be represented by different cortical regions.
背景/目的：不同的神经影像学技术表明，精神分裂症患者及存在幻听症状的患者，其听觉联合皮层和语言皮层会处于活跃状态。听觉性言语幻觉被认为源于内心言语障碍，但其起源却鲜为人知。
采用74通道双传感器系统（BIOMAGNES II）对16例精神分裂症患者和8名健康受试者进行自发性脑磁图（MEG）测量，频率范围为2至6赫兹以及12.5至30赫兹。在MEG记录过程中，有8例患者出现了幻听症状。
与健康受试者相比，精神分裂症患者总体在低频范围内的偶极子数量和偶极子密度最大值有统计学意义的升高（p <0.001）。仅在幻听期间发现高频范围内存在显著的偶极子活动（p <0.001）。根据幻觉的不同性质，偶极子定位集中在额叶和颞叶区域。在存在外部命令性幻听的患者中，我们发现背外侧额叶和颞叶皮层同时被激活。
我们得出结论，精神分裂症中各种幻听是由不同的神经元活动诱发的，且可能由不同的皮层区域所代表。
