Tesh R B, Gubler D J, Rosen L
Am J Trop Med Hyg. 1976 Mar;25(2):326-35. doi: 10.4269/ajtmh.1976.25.326.
Two types of variation were observed when the susceptibility of 16 different geographic strains of Aedes albopictus to oral infection with chikungunya (CHIK) virus was studied. One was differential susceptibility to infection with the virus. The other was variation in the quantity of virus present in infected mosquitoes after a standard incubation period. Mean virus titers of infected mosquitoes of different geographic strains varied almost 1,000-fold. Attempts to develop increasingly resistant or susceptible mosquito lines through genetic selection were unsuccessful. Infection rates did not change significantly despite 3 to 6 generations of selective inbreeding. In contrast, crosses between strains of high and low CHIK susceptibility yielded hybrid mosquitoes with infection rates and mean virus titers intermediate between those of the parent colonies. These data suggest that at least one factor controlling the susceptibility of A. albopictus to CHIK infection is genetic. Two lines of A. albopictus with a marked difference in susceptibility to oral infection with dengue viruses were equally susceptible to oral infection with chikungunya virus.
在研究16种不同地理株白纹伊蚊对基孔肯雅（CHIK）病毒口服感染的易感性时，观察到两种类型的变异。一种是对病毒感染的差异易感性。另一种是在标准潜伏期后感染蚊子体内存在的病毒量的变异。不同地理株感染蚊子的平均病毒滴度相差近1000倍。通过基因选择培育抗性或易感性越来越高的蚊系的尝试未成功。尽管进行了3至6代的选择性近亲繁殖，感染率并未显著变化。相比之下，CHIK易感性高的株系和低的株系之间的杂交产生了感染率和平均病毒滴度介于亲代群体之间的杂交蚊子。这些数据表明，至少有一个控制白纹伊蚊对CHIK感染易感性的因素是遗传的。对登革病毒口服感染易感性有显著差异的两个白纹伊蚊品系对基孔肯雅病毒口服感染的易感性相同。
