He Zhixiu, Liu Laikui, Chen Yan
College of Stomatology, West China University of Medical Sciences.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2002 Feb;20(1):27-9.
The aim of this study is to study genotype, transmission, clinical and pathological characteristics, and prognosis of oral condyloma acuminate (CA) in children.
The authors retrospected the clinical characteristics and slices of HE staining of six cases which have been diagnosed as oral CA and, performed inmunohistochemistry (IHC) and in situ hybridization (ISH) analysis to detect the DNA of human papilloma virus in 5 cases.
Oral CA often happened in the hard or soft plates of children of two-year-old. Most of them came from the families had been infected by human papilloma virus (HPV). Histological examination demonstrated that koilocytes were common in the upper spinous and corneal layers. HPV was detected in all cases. HPV16/18-E6 antigen was positive in 4 of 5 cases examined. The result of ISH only show one case was HPV6- and HPV11-positive, and the other case was HPV-positive, but HPV could not be detected when recurring.
The pathogen leading to oral condyloma acuminate (CA) and the transmission way of children may be different from that of adults.
本研究旨在探讨儿童口腔尖锐湿疣（CA）的基因型、传播途径、临床及病理特征和预后。
作者回顾了6例已诊断为口腔CA的临床特征及HE染色切片，并对其中5例进行免疫组织化学（IHC）和原位杂交（ISH）分析以检测人乳头瘤病毒（HPV）的DNA。
口腔CA常发生于2岁儿童的硬腭或软腭。多数患儿来自有HPV感染的家庭。组织学检查显示，棘层上部和角质层常见挖空细胞。所有病例均检测到HPV。5例检测中4例HPV16/18-E6抗原阳性。ISH结果显示仅1例HPV6和HPV11阳性，另1例HPV阳性，但复发时未检测到HPV。
导致儿童口腔尖锐湿疣（CA）的病原体及传播途径可能与成人不同。
