Muller S A, Landry M
Arch Dermatol. 1976 Mar;112(3):357-63. doi: 10.1001/archderm.112.3.357.
Two women had malignant atrophic papulosis that affected the skin only. Immunologic studies showed normal amounts of serum immunoglobulins and complement and normal delayed hypersensitivity skin test results. Fibrinolysis autografts showed complete loss of fibrinolysis within the lesions but normal fibrinolysis in uninvolved skin. Histopathologic studies showed moderate inflammatory infiltration consisting of lymphocytes in addition to the typical cone-shaped regions of necrobiosis. Large amounts of mucin also were seen. Endovasculitis, thrombosis, and perivascular lymphocytic inflammation were noted in the subcutaneous arterioles of the lesions in only one of the patients. Enzyme histochemical studies showed oxidative enzymes, although in reduced amounts, in the epidermal and dermal cells of the affected skin. Electron microscopic studies of lesions showed paromyxovirus-like inclusions in endothelial cells and fibroblasts. The possibility of an unusual viral causation should be examined further.
两名女性患有仅累及皮肤的恶性萎缩性丘疹病。免疫学研究显示血清免疫球蛋白和补体含量正常，迟发型超敏皮肤试验结果正常。纤维蛋白溶解自体移植显示病变部位纤维蛋白溶解完全丧失，但未受累皮肤的纤维蛋白溶解正常。组织病理学研究显示，除了典型的坏死性锥形区域外，还有由淋巴细胞组成的中度炎症浸润。还可见大量黏蛋白。仅在其中一名患者的病变皮下小动脉中观察到血管内皮炎、血栓形成和血管周围淋巴细胞炎症。酶组织化学研究显示，受累皮肤的表皮和真皮细胞中存在氧化酶，尽管含量减少。病变的电子显微镜研究显示内皮细胞和成纤维细胞中有类副黏液病毒样包涵体。应进一步研究不寻常病毒病因的可能性。
