Pallesen R M, Rasmussen N R
Acta Chir Scand. 1979;145(4):279-83.
A typical case of malignant atrophic papulosis is presented. The patient had had a symptomless, pathognomonic skin rash for 6 months and thereafter also multiple intestinal infarctions which caused perforations, peritonitis, and finally death. All therapeutic attempts, including intestinal resection and acetylsalicylic acid combined with dipyridamole, were in vain. Electron microscopy showed 200-250 A large virus-like cytoplasmic inclusions in the endothelial cells, without degenerative or regenerative changes, in a quite fresh papule. It was not possible to culture viruses on skin fibroblasts, but further studies of these inclusions are needed.
报告了一例典型的恶性萎缩性丘疹病。患者出现无症状的特征性皮疹6个月，此后又出现多处肠道梗死，导致穿孔、腹膜炎，最终死亡。所有治疗尝试，包括肠切除以及阿司匹林联合双嘧达莫，均告失败。电子显微镜检查显示，在一个相当新鲜的丘疹中，内皮细胞内有200 - 250埃的大型病毒样细胞质包涵体，无变性或再生性改变。无法在皮肤成纤维细胞上培养病毒，但需要对这些包涵体做进一步研究。
