Edwards S, Martog M, Pennock C A, Apley J
Arch Dis Child. 1976 Feb;51(2):149-52. doi: 10.1136/adc.51.2.149.
The urinary total hydroxyproline:creatinine ratio was measured on samples collected from 18 boys and 11 girls referred to a children's hospital because of small stature. Any serious degree of growth hormone deficiency was excluded and each child's growth and development was recorded over the following year. The hypothesis that the average hydroxyproline:creatinine ratio on random urine samples may be used to predict height velocity was examined. Such a prediction would have been incorrect on 35% of occasions, and it is concluded that this investigation cannot be used reliability to predict growth in height; it is probably only useful with sequential studies of an individual child over short periods while monitoring therapy.
对因身材矮小而转诊至儿童医院的18名男孩和11名女孩采集的样本进行了尿总羟脯氨酸与肌酐比值的测定。排除了任何严重程度的生长激素缺乏症，并记录了每个孩子在接下来一年中的生长发育情况。对随机尿样中平均羟脯氨酸与肌酐比值可用于预测身高增长速度这一假设进行了检验。这种预测在35%的情况下是不正确的，因此得出结论，这项研究不能可靠地用于预测身高增长；它可能仅在短期监测治疗期间对单个儿童进行连续研究时有用。
