恶性疟原虫寄生虫在临床免疫孕妇外周血中表达变异表面抗原表明存在持续性胎盘感染。
Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection.
作者信息
Ofori Michael F, Staalsoe Trine, Bam Victoria, Lundquist Maja, David Kim P, Browne Edmund N L, Akanmori Bartholomew D, Hviid Lars
机构信息
Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
出版信息
Infect Immun. 2003 Mar;71(3):1584-6. doi: 10.1128/IAI.71.3.1584-1586.2003.
Abstract
Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research.
摘要
导致临床上具有免疫力的女性发生妊娠相关疟疾（PAM）的胎盘隐匿型恶性疟原虫寄生虫表达非妊娠个体寄生虫所不表达的独特变异表面抗原（VSA(PAM)）。我们在此报告，临床上具有免疫力的孕妇外周血中的寄生虫也表达VSA(PAM)，这使其成为用于PAM疫苗研究的VSA(PAM)表达者的便利来源。
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