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恶性疟原虫寄生虫在临床免疫孕妇外周血中表达变异表面抗原表明存在持续性胎盘感染。

Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection.

作者信息

Ofori Michael F, Staalsoe Trine, Bam Victoria, Lundquist Maja, David Kim P, Browne Edmund N L, Akanmori Bartholomew D, Hviid Lars

机构信息

Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.

出版信息

Infect Immun. 2003 Mar;71(3):1584-6. doi: 10.1128/IAI.71.3.1584-1586.2003.

DOI:10.1128/IAI.71.3.1584-1586.2003
PMID:12595482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC148875/
Abstract

Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research.

摘要

导致临床上具有免疫力的女性发生妊娠相关疟疾（PAM）的胎盘隐匿型恶性疟原虫寄生虫表达非妊娠个体寄生虫所不表达的独特变异表面抗原（VSA(PAM)）。我们在此报告，临床上具有免疫力的孕妇外周血中的寄生虫也表达VSA(PAM)，这使其成为用于PAM疫苗研究的VSA(PAM)表达者的便利来源。

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本文引用的文献

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Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigens.疟疾诱导产生针对恶性疟原虫变异表面抗原的抗体。
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Malaria in pregnancy as an indirect cause of infant mortality in sub-Saharan Africa.撒哈拉以南非洲地区孕期疟疾作为婴儿死亡的间接原因
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Gravidity-dependent production of antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate proteoglycan during pregnancy.孕期依赖妊娠次数产生的抗体可抑制恶性疟原虫感染的红细胞与胎盘硫酸软骨素蛋白聚糖的结合。
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Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of Plasmodium falciparum-infected erythrocytes that protect against placental parasitemia.针对恶性疟原虫感染红细胞表面与妊娠相关的变异抗原的抗体的获得与衰减，这些抗体可预防胎盘寄生虫血症。
J Infect Dis. 2001 Sep 1;184(5):618-26. doi: 10.1086/322809. Epub 2001 Aug 9.
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The epidemiology and burden of Plasmodium falciparum-related anemia among pregnant women in sub-Saharan Africa.撒哈拉以南非洲地区孕妇中与恶性疟原虫相关贫血的流行病学及负担
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Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A.曾接触过疟疾的孕妇的血浆抗体以一种与胎次相关的方式识别恶性疟原虫感染红细胞上的可变表面抗原，并阻断寄生虫与硫酸软骨素A的黏附。
J Immunol. 2000 Sep 15;165(6):3309-16. doi: 10.4049/jimmunol.165.6.3309.
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Submicroscopic Plasmodium falciparum infections in pregnancy in Ghana.加纳孕期的恶性疟原虫亚显微感染
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Am J Trop Med Hyg. 1999 Sep;61(3):467-72. doi: 10.4269/ajtmh.1999.61.467.
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J Clin Microbiol. 1999 Sep;37(9):2992-6. doi: 10.1128/JCM.37.9.2992-2996.1999.