Nemenova N M, Turbina N S, Novikova T S, Faĩnshte in F E
Arkh Patol. 1976;38(1):52-8.
The authors present a broad pathoanatomic picture and concise clinical-laboratory characteristics of Marchiafava-Micheli's disease on the basis of their studies of case record date of 31 patients, data of 13 autopsies and findings of 27 treanobiopsies. Changes in the organs observed in Marchiafava-Micheli's disease were first of all morphological manifestations of massive intravascular hemolysis and associated with latter complications The most characteristic pathoanatomic feature was changes in the bone marrow which manifested themselves in hyperplasis of nuclear forms of the red series and in drastically pronounced disorders of the microcirculation. Necrobiotic changes in the kidney accompanied by massive hemosiderosis, dystrophic changes in the liver with the development of cirrhosis, inhibition of lymphopoiesiis in the spleen and lymph nodes were detected most often...
作者根据对31例患者病历资料、13例尸检数据及27例骨髓活检结果的研究，呈现了Marchiafava - Micheli病广泛的病理解剖情况及简明的临床实验室特征。Marchiafava - Micheli病中观察到的器官变化首先是大量血管内溶血的形态学表现，并与后者的并发症相关。最具特征性的病理解剖特征是骨髓变化，表现为红细胞系列核形态增生以及明显的微循环紊乱。最常检测到的是肾脏的坏死性变化伴大量含铁血黄素沉着、肝脏的营养不良性变化伴肝硬化形成、脾脏和淋巴结中淋巴细胞生成受抑制……
