Zachée P, Henckens M, Van Damme B, Boogaerts M A, Rigauts H, Verberckmoes R K
Department of Hematology, University Hospital, Leuven, Belgium.
Clin Nephrol. 1993 Jan;39(1):28-31.
We report on a 44-year-old man with paroxysmal nocturnal hemoglobinuria, who developed renal hemosiderosis, interstitial nephritis, and chronic renal failure. Classically, it is assumed that the renal function is only uncommonly affected by this pathology. In most instances the renal hemosiderosis is an incidental finding at postmortem examination. In our case the presence of iron in the kidney, as confirmed by CT scan, magnetic resonance imaging and renal biopsy, occurred concomitantly with the development of renal insufficiency. A direct nephrotoxic effect of iron by the induction of highly reactive hydroxyl radicals is suggested.
我们报告了一名44岁患有阵发性夜间血红蛋白尿的男性患者，该患者出现了肾含铁血黄素沉着症、间质性肾炎和慢性肾衰竭。传统上，人们认为这种病理情况很少影响肾功能。在大多数情况下，肾含铁血黄素沉着症是尸检时的偶然发现。在我们的病例中，经CT扫描、磁共振成像和肾活检证实，肾脏中铁的存在与肾功能不全的发展同时出现。提示铁通过诱导高反应性羟基自由基产生直接肾毒性作用。
