Svetyĭ L I, Alekhin S N
Clinical Pharmacology Department, Sechenov Medical Academy, ul. Bol'shaya Pirogovskaya 13, Moscow, 119881 Russia.
Eksp Klin Farmakol. 2002 Sep-Oct;65(5):35-8.
It was established that a regular administration of isradipine is accompanied by an increase in the mean values of Cmax (by 21.7%) and AUC (by 21.8%), which leads to extension of the pharmacodynamics effects without cumulation (the values of Clt, T1/2, and Tmax remain unchanged). The maximum hemodynamic effect of isradipine upon a single administration in a single dose of 5 mg coincides with the time or reaching the maximum drug concentration in the blood (Tmax). There is a reliable correlation between the hypotensive effect, the peripheral vascular resistance, and the concentration of isradipine.
