Kukes V G, Alekhin S N, Rumiantsev A S, Gneushev E T, Gushchin A S, Germanov D V
Eksp Klin Farmakol. 1993 Sep-Oct;56(5):38-41.
The paper deals with some aspects of the effects produced by dopegite on the pharmacokinetics and pharmacodynamics of foridone from a group of calcium antagonists. Nineteen patients with essential hypertension received a single doses of foridone of 40 mg, then its course therapy in a dose of 90 mg/day for 2 weeks, then it was supplemented with dopegite in a dose of 750 mg/day for 2 weeks too. Supplementation of dopegite caused statistically significant changes as higher plasma concentrations of foridone and increased concentration-time curve areas, decreased total peripheral resistance and regional, and a lower spasm index. Dopegite can be used to enhance the antihypertensive effect of foridone.
本文探讨了多培吉特对一组钙拮抗剂中福立酮的药代动力学和药效学产生的某些影响。19例原发性高血压患者单次服用40mg福立酮，然后以90mg/天的剂量进行为期2周的疗程治疗，之后同样以750mg/天的剂量补充多培吉特，为期2周。补充多培吉特导致了具有统计学意义的变化，如福立酮的血浆浓度更高、浓度-时间曲线面积增加、总外周阻力和局部阻力降低以及痉挛指数降低。多培吉特可用于增强福立酮的降压效果。
