Lu De-jian, Chen Yu-chuan, Lu Hui-ling
Department of Forensic Serology, Sun Yat-sen University of Medical Sciences, Guanzhou 510089.
Fa Yi Xue Za Zhi. 2002 May;18(2):118-20, 123.
Short tandem repeats (STRs) have been widely used in forensic sciences such as stain analysis and paternity testing. Although most of STR typing could give the reliable and clear results, some unusual typing have been observed in forensic practice. The anomalous typing could result from a lot of causes, including DNA genetic variation, poor quality or quantity of DNA template, different typing system or method, nonspecific reaction in PCR or anomalous electrophoresis migration. The unusual results may disturb the right interpretation of STR typing.
短串联重复序列(STRs)已广泛应用于诸如血迹分析和亲子鉴定等法医学领域。尽管大多数STR分型能够给出可靠且清晰的结果,但在法医学实践中仍观察到一些异常分型情况。这些异常分型可能由多种原因导致,包括DNA遗传变异、DNA模板质量或数量不佳、不同的分型系统或方法、PCR中的非特异性反应或异常的电泳迁移。这些异常结果可能会干扰对STR分型的正确解读。