Belaud A, Barthelemy L, Le Saint J, Peyraud C
Aviat Space Environ Med. 1976 Mar;47(3):252-7.
Specific effects of "per se" hydrostatic pressure on mean heart rate have been studied on eels (Anguilla anguilla L.), both untreated and treated with atropine and propranolol, and on isolated eel's heart. Because temperature brings, by itself, heart rate modifications in fish, a quantitative study was performed in order to take away the increment of heart rate due to the water warming, which cannot entirely be suppressed during compression. The specific effects of "per se" pressure have been identified as a bradycardia above 24.5 degrees C and as a tachycardia below this temperature. The use of atropine and propranol, which abolish extrinsic heart control, shows that pressure acts both through extrinsic mechanisms of heart control and through a direct action on autonomic cardiac cells. This effect of "per se" pressure on cardiac cells is interpreted according to chemical kinetics laws. The hypothesis that pressure acts at the molecular level, possibly by the means of reversible structure modifications of some molecules, is suggested.
研究了“本身的”静水压力对鳗鱼（欧洲鳗鲡）平均心率的特定影响，研究对象包括未经处理的鳗鱼、用阿托品和普萘洛尔处理过的鳗鱼以及离体鳗鱼心脏。由于温度本身会使鱼类的心率发生变化，因此进行了定量研究，以消除因水温升高导致的心率增加，而在压缩过程中这种增加无法完全抑制。已确定“本身的”压力的特定影响为在24.5摄氏度以上时出现心动过缓，在该温度以下时出现心动过速。使用阿托品和普萘洛尔消除心脏的外在控制，结果表明压力既通过心脏控制的外在机制起作用，也通过对自主心脏细胞的直接作用起作用。“本身的”压力对心脏细胞的这种作用是根据化学动力学定律来解释的。有人提出这样的假设：压力可能通过某些分子的可逆结构修饰在分子水平上起作用。
