Sebert P, Barthelemy L
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(1):207-12. doi: 10.1016/0742-8413(85)90231-2.
Cardiac responses to alpha and beta adrenergic drugs have been studied in the eel firstly at atmospheric pressure (1 ATA), secondly at 101 ATA per se hydrostatic pressure. The exposure of treated eels for 1 hr at 101 ATA cancels the propranolol effect, increases the clonidine effect and induces paradoxal effects (reversal effect) of isoproterenol, phentolamine and phenylephrine. The highly significant interaction (P less than 0.001) between drugs and HP at 101 ATA is discussed and interpreted as effects of hydrostatic pressure inducing a change in receptor function.
首先在大气压（1个绝对大气压）下，其次在101个绝对大气压的静水压力下，对鳗鱼心脏对α和β肾上腺素能药物的反应进行了研究。将处理过的鳗鱼在101个绝对大气压下暴露1小时，可消除普萘洛尔的作用，增强可乐定的作用，并诱发异丙肾上腺素、酚妥拉明和去氧肾上腺素的反常效应（反向效应）。讨论了在101个绝对大气压下药物与静水压力之间高度显著的相互作用（P小于0.001），并将其解释为静水压力诱导受体功能变化的效应。
