Steiness E, Olesen K H
Br Heart J. 1976 Feb;38(2):167-72. doi: 10.1136/hrt.38.2.167.
Twelve patients with congestive heart failure receiving maintenance therapy with digoxin and potent diuretics were followed closely during development of hypokalemia and potassium loss. Cardiac arrhythmias compatible with digoxtin toxicity developed in 6 patients in the presence of stable, normal serum digoxin concentrations. The mechanisms involved in the development of the rhythm disturbances are discussed with regard to hypokalaemia, intracellular potassium loss, intra-/extracellular potassium gradients and digoxin, and the significance of maintaining a normal potassium balance in this setting is stressed.
对12例接受地高辛和强效利尿剂维持治疗的充血性心力衰竭患者在发生低钾血症和钾丢失过程中进行了密切随访。6例患者在血清地高辛浓度稳定且正常的情况下出现了与地高辛毒性相符的心律失常。就低钾血症、细胞内钾丢失、细胞内外钾梯度和地高辛讨论了心律失常发生的机制，并强调了在这种情况下维持正常钾平衡的重要性。
