Smith A F, Radford D, Wong C P, Oliver M F
Br Heart J. 1976 Mar;38(3):225-32. doi: 10.1136/hrt.38.3.225.
Serial measurements of the MB isoenzyme of creatine kinase, total creatine kinase, aspartate mainotransferase, and urea stable lactate dehydrogenase have been made in the serum of a series of 139 patients admitted with a diagnosis of suspected myocardial infarction. Serum MB isoenzyme measurements have also been made on postoperative surgical patients and patients with medical disorders known to have caused raised serum total creatine kinase activity. All these enzymes were abnormal in at least one specimen from all patients with electrocardiographically proved acute myocardial infarction. The magnitude of the MB isoenzyme rise was 2 to 3 times greater than that of any of the other enzymes. The duration of its rise was relatively short. The MB isoenzyme was more specific for myocardial infarction than other enzymes and no increases were found in postoperative patients, except in those after cardiac bypass surgery. The MB isoenzyme seems the most sensitive and specific test for myocardial infarction available, though there are technical problems in its accurate measurement.
对一系列139例因疑似心肌梗死入院的患者血清进行了肌酸激酶MB同工酶、总肌酸激酶、天冬氨酸氨基转移酶和尿素稳定乳酸脱氢酶的系列测定。还对术后外科患者以及已知会导致血清总肌酸激酶活性升高的内科疾病患者进行了血清MB同工酶测定。所有经心电图证实为急性心肌梗死的患者，其至少一份标本中的所有这些酶均异常。MB同工酶升高的幅度比其他任何一种酶大2至3倍。其升高持续时间相对较短。MB同工酶对心肌梗死的特异性高于其他酶，除心脏搭桥手术后的患者外，术后患者未发现升高。MB同工酶似乎是现有用于心肌梗死的最敏感和特异的检测方法，尽管其准确测量存在技术问题。
