肌酸磷酸激酶同工酶MB（CPK-MB）与心肌梗死的诊断
Creatine phosphokinase-MB (CPK-MB) and the diagnosis of myocardial infarction.
作者信息
Guzy P M
出版信息
West J Med. 1977 Dec;127(6):455-60.
Abstract
Creatine phosphokinase-MB (CPK-MB) is the most sensitive and the most specific indicator available for the diagnosis of an acute myocardial infarction. With the exception of after-cardiac surgical procedures, the degree and the duration of CPK-MB elevation in serum approximates the extent of an acute myocardial infarction, although a variety of factors may affect the reliability of such an index. Differences in the fractionation and assay methods for the creatine phosphokinase isoenzymes have produced conflicting documentation as to the presence of CPK-MB in tissues other than myocardium and the release of CPK-MB under conditions other than an acute myocardial infarction. The embryological development of the CPK-MB isoenzymes, as well as the various conditions involving increased CPK-BB serum activity, also deserve attention.
摘要
肌酸磷酸激酶同工酶MB（CPK-MB）是诊断急性心肌梗死最敏感、最特异的指标。除心脏手术后外，血清中CPK-MB升高的程度和持续时间与急性心肌梗死的范围大致相符，尽管多种因素可能影响该指标的可靠性。肌酸磷酸激酶同工酶的分离和检测方法存在差异，这导致关于CPK-MB在心肌以外组织中的存在以及在急性心肌梗死以外情况下CPK-MB的释放存在相互矛盾的文献记载。CPK-MB同工酶的胚胎发育以及涉及血清CPK-BB活性增加的各种情况也值得关注。
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本文引用的文献
1
THE ONTOGENY OF CREATINE KINASE ISOZYMES.
Dev Biol. 1964 Aug;10:1-16. doi: 10.1016/0012-1606(64)90002-8.
2
Unrecognized myocardial infarction; a clinicopathologic study.
AMA Arch Intern Med. 1959 Feb;103(2):253-61. doi: 10.1001/archinte.1959.00270020081009.
3
Serum glutamic oxaloacetic transaminase activity in human acute transmural myocardial infarction.
Science. 1954 Sep 24;120(3117):497-9. doi: 10.1126/science.120.3117.497.
4
Creatin kinase in human tissues.
Arch Neurol. 1967 Feb;16(2):175-80. doi: 10.1001/archneur.1967.00470200063005.
5
The comparative enzymology of creatine kinases. I. Isolation and characterization from chicken and rabbit tissues.
J Biol Chem. 1967 Jan 25;242(2):204-9.
6
Isoenzymes of creatine phosphokinase in tissue extracts and in normal and pathological sera.
Clin Chim Acta. 1966 Mar;13(3):312-6. doi: 10.1016/0009-8981(66)90209-9.
7
Serum enzymes in diseases of the thyroid gland.
J Clin Pathol. 1965 Sep;18(5):660-3. doi: 10.1136/jcp.18.5.660.
8
Creatine phosphokinase isozymes in muscles. Human fetus and patients.
Arch Neurol. 1969 Apr;20(4):422-9. doi: 10.1001/archneur.1969.00480100098014.
9
Creatine kinase isoenzymes and the role of thiol groups in the enzymic mechanism.
Biochemistry. 1968 Jun;7(6):2063-71. doi: 10.1021/bi00846a007.
10
Depressed myocardial creatine phosphokinase activity following experimental myocardial infarction in rabbit.
Circ Res. 1970 Sep;27(3):403-14. doi: 10.1161/01.res.27.3.403.
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