Brummer Elmer, Kamberi Marika, Stevens David A
Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose, California 95128-2669, USA.
J Infect Dis. 2003 Feb 15;187(4):705-9. doi: 10.1086/368383. Epub 2003 Feb 7.
Production of the proinflammatory cytokines interleukin (IL)-1 alpha and tumor necrosis factor (TNF)-alpha and of the chemotactic chemokine macrophage inflammatory protein (MIP)-1 alpha by bronchoalveolar macrophages (BAMs) from mice in response to Aspergillus conidia was tested after in vivo administration of saline, dexamethasone, cortisone acetate, granulocyte-macrophage colony-stimulating factor (GM-CSF), or a combination. Dexamethasone suppressed production of IL-1 alpha, TNF-alpha, and MIP-1 alpha; GM-CSF reduced secretion slightly but antagonized dexamethasone suppression when the two were given in combination. Cortisone acetate gave results similar to dexamethasone, but cortisone acetate suppression of BAM responses lasted 7 days, > or = 4 days longer than dexamethasone suppression. The effect of GM-CSF on cortisone acetate suppression lasted at least 7 days. GM-CSF could promote resistance to conidia by maintaining proinflammatory responses.
在对小鼠进行体内给予生理盐水、地塞米松、醋酸可的松、粒细胞-巨噬细胞集落刺激因子（GM-CSF）或联合用药后，检测了支气管肺泡巨噬细胞（BAM）对烟曲霉菌分生孢子产生促炎细胞因子白细胞介素（IL）-1α和肿瘤坏死因子（TNF）-α以及趋化性趋化因子巨噬细胞炎性蛋白（MIP）-1α的情况。地塞米松抑制IL-1α、TNF-α和MIP-1α的产生；GM-CSF略微降低分泌，但当二者联合给予时可拮抗地塞米松的抑制作用。醋酸可的松的结果与地塞米松相似，但醋酸可的松对BAM反应的抑制持续7天，比地塞米松抑制长≥4天。GM-CSF对醋酸可的松抑制的作用至少持续7天。GM-CSF可通过维持促炎反应来促进对分生孢子的抵抗力。
