从核动力学角度考虑核区室化。

Considering nuclear compartmentalization in the light of nuclear dynamics.

作者信息

Chubb Jonathan R, Bickmore Wendy A

机构信息

MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, United Kingdom.

出版信息

Cell. 2003 Feb 21;112(4):403-6. doi: 10.1016/s0092-8674(03)00078-3.

DOI:10.1016/s0092-8674(03)00078-3

PMID:12600306

Abstract

Many proteins are concentrated in compartments within the nucleus. Chromatin is also compartmentalized at different nuclear sites. However, nuclear proteins have now been shown to be highly mobile. This review considers the formation and function of nuclear compartments in a situation in which proteins are rapidly moving through the nuclear volume.

摘要

许多蛋白质集中在细胞核内的不同区域。染色质在细胞核的不同位点也呈区域化分布。然而，现已证明核蛋白具有高度的流动性。本综述探讨了在蛋白质快速穿梭于核内空间的情况下，核区室的形成及其功能。