紫外线辐射诱发的白内障：年龄与最大可接受剂量

Ultraviolet radiation-induced cataract: age and maximum acceptable dose.

作者信息

Dong Xiuqin, Ayala Marcelo, Löfgren Stefan, Söderberg Per G

机构信息

Research Department, St Erik's Eye Hospital, Karolinska Institute, Stockholm, Sweden.

出版信息

Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1150-4. doi: 10.1167/iovs.02-0541.

DOI:10.1167/iovs.02-0541

PMID:12601043

Abstract

PURPOSE

To investigate the effect of age on ultraviolet radiation-B (UVR-B)-induced cataract and to detect the maximum acceptable dose in rats of different age groups.

METHODS

Four age groups of 20 rats each, aged 3, 6, 10, and 18 weeks, were included. Each age group was divided into five UVR-B dose subgroups. The rats were unilaterally exposed to UVR-B (lambda(max) = 302.6 nm, lambda(0.5) = 4.5 nm). The incident dose on the cornea varied between 0 and 8 kJ/m(2). One week after exposure, the rats were killed, both lenses were extracted, the intensity of forward light-scattering was measured, and photographs were taken. The sensitivity of the lens to UVR-B was estimated as the maximum acceptable dose.

RESULTS

The maximum acceptable dose for 3-, 6-, 10-, and 18-week-old rats was estimated to be 1.4, 2.7, 4.3 and 5.2 kJ/m(2), respectively.

CONCLUSIONS

Young rats were more sensitive to UVR-B than old ones. Age should be considered when estimating the risk for UVR-B-induced cataract.

摘要

目的

研究年龄对紫外线B（UVR-B）诱导的白内障的影响，并检测不同年龄组大鼠的最大可接受剂量。

方法

纳入四个年龄组，每组20只大鼠，年龄分别为3周、6周、10周和18周。每个年龄组再分为五个UVR-B剂量亚组。大鼠单侧暴露于UVR-B（λmax = 302.6 nm，λ0.5 = 4.5 nm）。角膜上的入射剂量在0至8 kJ/m²之间变化。暴露一周后，处死大鼠，取出双侧晶状体，测量前向光散射强度并拍照。晶状体对UVR-B的敏感性以最大可接受剂量来估计。