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服用地芬诺酯后血浆中地芬诺酸的测定。

The measurement of diphenoxylic acid in plasma following administration of diphenoxylate.

作者信息

Ford G C, Haskins N J, Palmer R F, Tidd M J, Buckley P H

出版信息

Biomed Mass Spectrom. 1976 Feb;3(1):45-7. doi: 10.1002/bms.1200030109.

DOI:10.1002/bms.1200030109
PMID:1260116
Abstract

The measurement of diphenoxylic acid, the major metabolite of diphenoxylate, has been performed in man using a deuterium labelled internal standard and multiple ion monitoring using a gas chromatograph mass spectrometer. The determination of plasma concentrations following administration of diphenoxylate to man is described.

摘要

使用氘标记内标物并通过气相色谱 - 质谱仪进行多离子监测,在人体中对苯乙哌啶的主要代谢产物二苯氧基酸进行了测定。本文描述了给人体服用苯乙哌啶后血浆浓度的测定情况。

相似文献

1
The measurement of diphenoxylic acid in plasma following administration of diphenoxylate.服用地芬诺酯后血浆中地芬诺酸的测定。
Biomed Mass Spectrom. 1976 Feb;3(1):45-7. doi: 10.1002/bms.1200030109.
2
The evaluation and application of a radioimmunoassay for the measurement of diphenoxylic acid, the major metabolite of diphenoxylate hydrochloride (Lomotil), in human plasma.用于测量盐酸地芬诺酯(易蒙停)主要代谢物二苯氧基酸在人血浆中含量的放射免疫分析方法的评估与应用。
J Pharmacol Methods. 1987 Nov;18(3):189-97. doi: 10.1016/0160-5402(87)90069-6.
3
Pharmacokinetics and metabolism of diphenoxylate in man.地芬诺酯在人体中的药代动力学与代谢
Clin Pharmacol Ther. 1972 May-Jun;13(3):407-19. doi: 10.1002/cpt1972133407.
4
Use of diphenoxylate (Lomotil) in children.
Indian Pediatr. 1984 Jul;21(7):582-3.
5
Determination of diphenoxylate hydrochloride and atropine sulfate in solutions and tablets.溶液和片剂中盐酸地芬诺酯与硫酸阿托品的测定
J Pharm Sci. 1977 Nov;66(11):1553-6. doi: 10.1002/jps.2600661113.
6
[Warning against the use of diphenoxylate (Reasec) by children with diarrhea].[腹泻儿童使用地芬诺酯(Reasec)的警告]
Ned Tijdschr Geneeskd. 1983 May 21;127(21):911-2.
7
Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 6. Absorption, excretion and metabolism in man.
Arzneimittelforschung. 1972 Mar;22(3):529-31.
8
In vitro adsorption of diphenoxylate hydrochloride on activated charcoal and its relationship to pharmacological effects of drug in vivo. I.
J Pharm Sci. 1975 Nov;64(11):1877-9. doi: 10.1002/jps.2600641129.
9
Simultaneous determination of ketobemidone and its N-demethylated metabolite in patient plasma samples by gas chromatography mass spectrometry with selected ion monitoring.采用气相色谱-质谱联用选择离子监测法同时测定患者血浆样本中的凯托米酮及其N-去甲基代谢物。
Biomed Mass Spectrom. 1983 Apr;10(4):283-6. doi: 10.1002/bms.1200100410.
10
Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 4. Distribution in the rat of diphenoxylate and difenoxine.
Arzneimittelforschung. 1972 Mar;22(3):520-6.

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Clin Pharmacokinet. 1990 Aug;19(2):94-125. doi: 10.2165/00003088-199019020-00002.
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Respiratory depression due to unsuspected narcotic ingestion treated with naloxone.因意外摄入麻醉品导致呼吸抑制,用纳洛酮进行治疗。
Arch Dis Child. 1978 Jun;53(6):508-9. doi: 10.1136/adc.53.6.508.