从盖氏风车子心材中分离出的化合物的抗真菌、抗氧化和杀幼虫活性。

Antifungal, antioxidant and larvicidal activities of compounds isolated from the heartwood of Mansonia gagei.

作者信息

Tiew P, Ioset J R, Kokpol U, Chavasiri W, Hostettmann K

机构信息

Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 Lausanne, Switzerland.

出版信息

Phytother Res. 2003 Feb;17(2):190-3. doi: 10.1002/ptr.1260.

DOI:10.1002/ptr.1260

PMID:12601687

Abstract

Eleven compounds isolated from the heartwood of Mansonia gagei were tested for their antifungal activities against Cladosporium cucumerinum and Candida albicans, as well as for their larvicidal activities against Aedes aegypti and radical scavenging properties in a DPPH assay. Mansonone C (4) was found to be the most interesting compound with antifungal activities against Cladosporium cucumerinum and Candida albicans as well as for its larvicidal properties against Aedes aegypti. Mansonone E (5) was active against Cladosporium cucumerinum and Candida albicans. Two coumarin derivatives, mansorin A (1) and mansorin B (2) were also found to be active against Cladosporium cucumerinum, while mansonone N (9) was the only isolated product to show radical scavenging properties.

摘要

对从曼森玉蕊（Mansonia gagei）心材中分离出的11种化合物进行了测试，检测它们对黄瓜枝孢菌（Cladosporium cucumerinum）和白色念珠菌（Candida albicans）的抗真菌活性，以及对埃及伊蚊（Aedes aegypti）的杀幼虫活性，并通过DPPH试验检测其自由基清除特性。发现曼森酮C（4）是最具吸引力的化合物，它对黄瓜枝孢菌和白色念珠菌具有抗真菌活性，对埃及伊蚊也具有杀幼虫特性。曼森酮E（5）对黄瓜枝孢菌和白色念珠菌有活性。还发现两种香豆素衍生物，曼索林A（1）和曼索林B（2）对黄瓜枝孢菌有活性，而曼森酮N（9）是唯一显示出自由基清除特性的分离产物。