来自诺丽波罗蜜茎皮的具有抗真菌和自由基清除特性的芪衍生物。

Stilbene derivatives with antifungal and radical scavenging properties from the stem bark of Artocarpus nobilis.

作者信息

Jayasinghe U L B, Puvanendran S, Hara N, Fujimoto Y

机构信息

Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka.

出版信息

Nat Prod Res. 2004 Dec;18(6):571-4. doi: 10.1080/14786410310001643867.

DOI:10.1080/14786410310001643867

PMID:15595616

Abstract

Antifungal activity-guided fractionation of the n-butanol extract from the methanol extract of the stem bark of Artocarpus nobilis furnished two stilbene derivatives (E)-4-isopentenyl-3,5,2',4'-tetrahydroxystilbene and (E)-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene. Both compounds showed strong antifungal activity against Cladosporium cladosporioides and high radical scavenging activity towards the DPPH radical in TLC bio-autography method.

摘要

对面包树茎皮甲醇提取物的正丁醇提取物进行抗真菌活性导向分离，得到两种芪衍生物：（E）-4-异戊烯基-3,5,2',4'-四羟基芪和（E）-4-（3-甲基-E-丁-1-烯基）-3,5,2',4'-四羟基芪。在薄层色谱生物自显影法中，这两种化合物对枝孢霉菌均表现出较强的抗真菌活性，对DPPH自由基具有较高的自由基清除活性。