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巴西苏木素来源于苏木属植物巴西苏木，具有抗氧化、抑制脂肪细胞分化和诱导细胞凋亡的作用，其作用机制与激活 caspase-3 活性有关。此外，巴西苏木素还具有抗蠕虫活性，能够有效对抗微小膜壳绦虫和简单异尖线虫。

Brazilein from Caesalpinia sappan L. Antioxidant Inhibits Adipocyte Differentiation and Induces Apoptosis through Caspase-3 Activity and Anthelmintic Activities against Hymenolepis nana and Anisakis simplex.

机构信息

Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.

出版信息

Evid Based Complement Alternat Med. 2013;2013:864892. doi: 10.1155/2013/864892. Epub 2013 Mar 11.

DOI:10.1155/2013/864892
PMID:23554834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3608347/
Abstract

Brazilein, a natural, biologically active compound from Caesalpinia sappan L., has been shown to exhibit anti-inflammatory and antioxidant properties and to inhibit the growth of several cancer cells. This study verifies the antioxidant and antitumor characteristics of brazilein in skin cancer cells and is the first time to elucidate the inhibition mechanism of adipocyte differentiation, cestocidal activities against Hymenolepis nana, and reduction of spontaneous movement in Anisakis simplex. Brazilein exhibits an antioxidant capacity as well as the ability to scavenge DPPH(•) and ABTS(•+) free radicals and to inhibit lipid peroxidation. Brazilein inhibited intracellular lipid accumulation during adipocyte differentiation in 3T3-L1 cells and suppressed the induction of peroxisome proliferator-activated receptor γ (PPAR γ ), the master regulator of adipogenesis, suggesting that brazilein presents the antiobesity effects. The toxic effects of brazilein were evaluated in terms of cell viability, induction of apoptosis, and the activity of caspase-3 in BCC cells. The inhibition of the growth of skin cancer cells (A431, BCC, and SCC25) by brazilein is greater than that of human skin malignant melanoma (A375) cells, mouse leukemic monocyte macrophage (RAW 264.7 cells), and noncancerous cells (HaCaT and BNLCL2 cells). The anthelmintic activities of brazilein against Hymenolepis nana are better than those of Anisakis simplex.

摘要

巴西红厚壳素是一种天然的、具有生物活性的化合物，来源于苏木属植物巴西苏木，已被证明具有抗炎和抗氧化特性，并能抑制多种癌细胞的生长。本研究验证了巴西红厚壳素在皮肤癌细胞中的抗氧化和抗肿瘤特性，这也是首次阐明其对脂肪细胞分化的抑制机制、对曼氏迭宫绦虫的杀绦虫活性以及对秀丽隐杆线虫自发运动的减少作用。巴西红厚壳素有抗氧化能力，能够清除 DPPH(•)和 ABTS(•+)自由基，并抑制脂质过氧化。巴西红厚壳素抑制了 3T3-L1 细胞中脂肪细胞分化过程中的细胞内脂质积累，并抑制过氧化物酶体增殖物激活受体 γ（PPARγ）的诱导，后者是脂肪生成的主调控因子，提示巴西红厚壳素具有抗肥胖作用。通过细胞活力、细胞凋亡诱导和 BCC 细胞中 caspase-3 的活性评估了巴西红厚壳素的毒性作用。巴西红厚壳素对皮肤癌细胞（A431、BCC 和 SCC25）的生长抑制作用大于对人皮肤恶性黑色素瘤（A375）细胞、小鼠白血病单核巨噬细胞（RAW 264.7 细胞）和非癌细胞（HaCaT 和 BNLCL2 细胞）的生长抑制作用。巴西红厚壳素对曼氏迭宫绦虫的驱虫活性优于对秀丽隐杆线虫的驱虫活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/77b3893cfa9e/ECAM2013-864892.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/14d477149bc2/ECAM2013-864892.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/5f43a4bc7e1b/ECAM2013-864892.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/0abb56f2dea4/ECAM2013-864892.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/3f80d3b5882e/ECAM2013-864892.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/a570c9374dec/ECAM2013-864892.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/77b3893cfa9e/ECAM2013-864892.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/14d477149bc2/ECAM2013-864892.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/5f43a4bc7e1b/ECAM2013-864892.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/0abb56f2dea4/ECAM2013-864892.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/3f80d3b5882e/ECAM2013-864892.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/a570c9374dec/ECAM2013-864892.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2277/3608347/77b3893cfa9e/ECAM2013-864892.006.jpg

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