Yu Chen-Hsiang, Chang Chiung-Hsing, Ko Huei-Chen, Chen Wen-Chu, Chang Fong-Ming
Department of Obstetrics and Gynecology, National Chen Kung University Medical College and Hospital, Tainan, Taiwan.
Ultrasound Med Biol. 2003 Jan;29(1):19-23. doi: 10.1016/s0301-5629(02)00695-6.
To test the hypothesis that the placental fractional moving blood volume is different with advancing gestational age (GA), we assessed the vascularization index (VI), flow index (FI), and vascularization-flow index (VFI) of the placenta in normal pregnancy by using three-dimensional (3-D) power Doppler ultrasound (US). We enrolled 100 healthy pregnant women with gestational age between 20 to 40 weeks for this study. Three-dimensional power Doppler ultrasonography was used to assess the VI, FI and VFI in each case. Our results showed that the linear regression equations for VI, FI and VFI, by using GA as the independent variable, were VI = 0.27107 x GA -4.02748 (r = 0.84, p < 0.0001), FI = 0.56115 x GA + 34.28945 (r = 0.49, p < 0.001), and VFI = 0.15663 x GA -2.53810 (r = 0.82, p < 0.0001), respectively. In addition, the VI, FI and VFI values of the placental flow were also positively correlated with the fetal growth indices, namely, biparietal diameter, occipitofrontal diameter, head circumference, abdominal circumference and estimated fetal weight (all p values < 0.001). In conclusion, our study illustrates that the fractional moving blood volume of the placenta is positively correlated with the increment of gestational age and the fetal growth indices. Our data may be used as a reference in the assessment of the placental fractional moving blood volume using the quantitative 3-D power Doppler US.
为验证胎盘移动血容量分数随孕周增加而变化的假说，我们采用三维能量多普勒超声评估了正常妊娠胎盘的血管化指数（VI）、血流指数（FI）和血管化血流指数（VFI）。本研究纳入了100例孕周在20至40周之间的健康孕妇。采用三维能量多普勒超声对每例孕妇的VI、FI和VFI进行评估。我们的结果显示，以孕周作为自变量，VI、FI和VFI的线性回归方程分别为VI = 0.27107×孕周 - 4.02748（r = 0.84，p < 0.0001），FI = 0.56115×孕周 + 34.28945（r = 0.49，p < 0.001），以及VFI = 0.15663×孕周 - 2.53810（r = 0.82，p < 0.0001）。此外，胎盘血流的VI、FI和VFI值也与胎儿生长指标呈正相关，即双顶径、枕额径、头围、腹围和估计胎儿体重（所有p值均< 0.001）。总之，我们的研究表明，胎盘移动血容量分数与孕周增加及胎儿生长指标呈正相关。我们的数据可作为使用定量三维能量多普勒超声评估胎盘移动血容量分数的参考。
