Biesold D, Brückner G, Mares V
Brain Res. 1976 Mar 12;104(2):295-301. doi: 10.1016/0006-8993(76)90621-1.
Rats pregnant for 14, 16, 18 and 20 days, as well as 1-, 3-, 7-, 12-, 16- and 21-day-old offspring, received a single injection of [3H]thymidine and were killed at postnatal ages of 22-27 days. An autoradiographic study of DNA synthesis revealed that proliferation of non-neuronal matrix cell precursors destined for the dorsal part of the lateral geniculate nucleus had already started by gestational day 14. Quantiative evaluation of the incidence of labelled cells revealed 2 peaks occurring in both groups of non-neuronal cells at postnatal days (PD) 7 and 16. It has been assumed that the accelerated production of ectodermally derived glial cells, observed towards PD 7, relfects the enhanced growth of the neuronal surface covered with glial cell processes, and that at PD 16 formation of myelin sheaths. Changes in the number of labelled cells of mesodermal origin in the course of development can probably be attributed to the rate of vasculogenesis of the studied region.
怀孕14、16、18和20天的大鼠，以及出生1、3、7、12、16和21天的后代，接受单次注射[3H]胸腺嘧啶核苷，并在出生后22 - 27天处死。一项关于DNA合成的放射自显影研究表明，注定要进入外侧膝状体核背侧部分的非神经元基质细胞前体的增殖在妊娠第14天就已经开始。对标记细胞发生率的定量评估显示，两组非神经元细胞在出生后第7天和第16天出现两个峰值。据推测，在出生后第7天观察到的外胚层来源的神经胶质细胞加速产生，反映了被神经胶质细胞突起覆盖的神经元表面的生长增强，而在出生后第16天则是髓鞘形成。在发育过程中，中胚层来源的标记细胞数量的变化可能归因于所研究区域的血管生成速率。
