Parnavelas J G, Mounty E J, Bradford R, Lieberman A R
J Comp Neurol. 1977 Feb 15;171(4):481-99. doi: 10.1002/cne.901710405.
The postnatal differentiation of neurons in the dorsal lateral geniculate nucleus of the albino rat was studied using the Golgi-Cox technique. At least four animals were used at postnatal ages 12 hours, 2, 4, 6, 8, 10, 11, 12, 13, 14, 15, 16, 18, 20, 24, 28, 35 days and adult. Presumptive thalamo-cortical projection cells (Class A cells of Grossman et al., '73) and non-projection, intrinsic neurons (Class B cells) are distinguishable at 12 hours after birth. At this stage both types of neuron are immature, with prominent growth cones at their dendritic extremities. Dendritic growth and differentiation appear to be complete by 18 days. Relay cells display two apparent "growth spurts" characterized by noticeable enlargement of the perikaryon and a marked increase in dendritic length and complexity. One occurs between days 4 and 6 and coincides with a period of enhanced synaptogenesis and gliogenesis: the second occurs between days 14 and 15, around the time of eye opening (day 14) and may be related to a further phase of increased synaptogenesis and gliogenesis (Karlsson, '67; Biesold et al., '76). Class B cells appear to "lag" behind class A cells in their initial postnatal differentiation, but also reach their mature condition by day 18.
采用高尔基-考克斯技术研究了白化大鼠背外侧膝状核神经元的产后分化。使用了至少四只动物，分别处于出生后12小时、2天、4天、6天、8天、10天、11天、12天、13天、14天、15天、16天、18天、20天、24天、28天、35天以及成年期。出生后12小时可区分出推测的丘脑-皮质投射细胞（格罗斯曼等人，1973年的A类细胞）和非投射性的内在神经元（B类细胞）。在这个阶段，两种类型的神经元都不成熟，其树突末端有明显的生长锥。树突的生长和分化在18天时似乎完成。中继细胞表现出两个明显的“生长高峰”，其特征是胞体明显增大，树突长度和复杂性显著增加。一个发生在第4天到第6天之间，与突触发生和胶质细胞生成增强的时期一致；第二个发生在第14天到第15天之间，大约在睁眼（第14天）时，可能与突触发生和胶质细胞生成增加的进一步阶段有关（卡尔松，1967年；比索尔德等人，1976年）。B类细胞在出生后的初始分化中似乎比A类细胞“滞后”，但到18天时也达到成熟状态。
