MacLean L D, Meakins J L, Taguchi K, Duignan J P, Dhillon K S, Gordon J
Ann Surg. 1975 Sep;182(3):207-17. doi: 10.1097/00000658-197509000-00004.
Host resistance to infection was measured by the in vivo response to 5 delayed hypersensitivity antigens and to sensitivity and challenge by dinitrochlorobenzene (DNCB) in 55 seriously ill or injured patients and in 50 preoperative patients. A close correlation between infections, septicemia, death related to infection and anergy was found in the postoperative and post injury patients and was predictive of these complications in the patients studied preoperatively. Decreased body cell mass was noted in both the anergic and non-anergic patients which was consistent with protein-calorie malnutrition but the two groups were not significantly different. A serum factor which inhibited cellular immunity in vitro was found in 4 patients. This factor disappeared in the two patients who recovered. The study suggests the therapeutic value of the in vivo measurement of delayed hypersensitivity in seriously ill and especially preoperative patients in whom specific or non-specific stimulation of cell mediated immunity might alter the risk of infection.
通过对55名重症或受伤患者以及50名术前患者对5种迟发型超敏反应抗原的体内反应、对二硝基氯苯（DNCB）的敏感性和激发反应来衡量宿主对感染的抵抗力。在术后和受伤后的患者中，发现感染、败血症、感染相关死亡与无反应性之间存在密切相关性，并且在术前研究的患者中可预测这些并发症。在无反应性和有反应性患者中均发现身体细胞质量下降，这与蛋白质 - 热量营养不良一致，但两组之间无显著差异。在4名患者中发现一种体外抑制细胞免疫的血清因子。在康复的两名患者中该因子消失。该研究表明，对重症尤其是术前患者进行迟发型超敏反应的体内测量具有治疗价值，在这些患者中，细胞介导免疫的特异性或非特异性刺激可能会改变感染风险。
