内分泌腺源性VEGF同源物Bv8促进睾丸血管生成：Bv8受体在内皮细胞中的定位。
The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells.
作者信息
LeCouter Jennifer, Lin Rui, Tejada Max, Frantz Gretchen, Peale Franklin, Hillan Kenneth J, Ferrara Napoleone
机构信息
Department of Molecular Oncology, Genentech, Inc., South San Francisco, CA 94080, USA.
出版信息
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2685-90. doi: 10.1073/pnas.0337667100. Epub 2003 Feb 25.
We recently identified an angiogenic mitogen, endocrine-gland-derived vascular endothelial growth factor (EG-VEGF), with selective activity for endothelial cells of endocrine tissues. Here we describe the characterization of a highly related molecule, Bv8, also known as prokineticin-2. Human Bv8 shares 60% identity and 75% similarity with EG-VEGF. The human and mouse Bv8 genes share a common structure. Like EG-VEGF, Bv8 is able to induce proliferation, survival and migration of adrenal cortical capillary endothelial cells. Bv8 gene expression is induced by hypoxic stress. Bv8 expression occurs predominantly in the testis and is largely restricted to primary spermatocytes. Adenoviral delivery of Bv8 or EG-VEGF to the mouse testis resulted in a potent angiogenic response. We have localized the expression of the Bv8EG-VEGF receptors within the testis to vascular endothelial cells. The testis exhibits relatively high turnover of endothelial cells. Therefore, Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis.
我们最近鉴定出一种血管生成促分裂原，即内分泌腺源性血管内皮生长因子（EG-VEGF），它对内分泌组织的内皮细胞具有选择性活性。在此，我们描述了一种高度相关分子Bv8（也称为促动力蛋白-2）的特性。人Bv8与EG-VEGF的同源性为60%，相似性为75%。人和小鼠的Bv8基因具有共同的结构。与EG-VEGF一样，Bv8能够诱导肾上腺皮质毛细血管内皮细胞的增殖、存活和迁移。Bv8基因表达受缺氧应激诱导。Bv8主要在睾丸中表达，并且很大程度上局限于初级精母细胞。将Bv8或EG-VEGF通过腺病毒递送至小鼠睾丸会导致强烈的血管生成反应。我们已将Bv8/EG-VEGF受体的表达定位在睾丸内的血管内皮细胞上。睾丸内皮细胞的更新相对较快。因此，Bv8和EG-VEGF与其他因子（如VEGF-A）一起，可能维持睾丸血管的完整性并调节其增殖。
Zotero 插件