肥胖儿童循环前动力蛋白2水平升高且与胰岛素抵抗相关。

Circulating Prokineticin 2 Levels Are Increased in Children with Obesity and Correlated with Insulin Resistance.

作者信息

Wang Han, Jia Yanjun, Yu Xiaoyan, Peng Li, Mou Chunfeng, Song Zhixin, Chen Dapeng, Li Xiaoqiang

机构信息

Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing Key Laboratory of Child Health and Nutrition, Chongqing 400014, China.

Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.

出版信息

Int J Endocrinol. 2021 Apr 4;2021:6630102. doi: 10.1155/2021/6630102. eCollection 2021.

DOI:10.1155/2021/6630102

PMID:33883996

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8041561/

Abstract

OBJECTIVE

Prokineticin 2 (PK2) has been shown to regulate food intake, fat production, and the inflammation process, which play vital roles in the pathogenesis of obesity. The first aim of this study was to investigate serum PK2 levels in children with obesity and normal-weight children. The second aim was to compare the levels of PK2 between children with obesity, with and without nonalcoholic fatty liver disease (NAFLD).

METHODS

Seventy normal-weight children and 91 children with obesity (22 with NAFLD) were recruited. Circulating PK2, IL-6, and TNF- were measured by enzyme-linked immunosorbent assays. Anthropometric and biochemical measurements related to adiposity, lipid profile, and insulin resistance were examined for all participants.

RESULTS

Serum PK2 was significantly higher in children with obesity than in the normal-weight controls. Circulating PK2 levels were not different between the patients with and without NAFLD. Circulating PK2 was positively correlated with BMI, BMI z-score, insulin, glucose, HOMA-IR, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, and gamma-glutamyl transpeptidase. Binary logistic regression revealed that the odds ratios for obesity were significantly elevated with increasing PK2.

CONCLUSIONS

PK2 was strongly associated with obesity, and it may also be related to metabolic disorders and insulin resistance. This trial is registered with ChiCTR2000038838.

摘要

目的

促动力蛋白2（PK2）已被证明可调节食物摄入、脂肪生成和炎症过程，这些在肥胖发病机制中起着至关重要的作用。本研究的首要目的是调查肥胖儿童和正常体重儿童的血清PK2水平。第二个目的是比较伴有和不伴有非酒精性脂肪性肝病（NAFLD）的肥胖儿童之间的PK2水平。

方法

招募了70名正常体重儿童和91名肥胖儿童（22名患有NAFLD）。通过酶联免疫吸附测定法测量循环中的PK2、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。对所有参与者进行了与肥胖、血脂谱和胰岛素抵抗相关的人体测量和生化检测。

结果

肥胖儿童的血清PK2显著高于正常体重对照组。伴有和不伴有NAFLD的患者之间循环PK2水平无差异。循环PK2与体重指数（BMI）、BMI z评分、胰岛素、血糖、稳态模型评估的胰岛素抵抗（HOMA-IR）、总胆固醇、低密度脂蛋白胆固醇、丙氨酸转氨酶和γ-谷氨酰转肽酶呈正相关。二元逻辑回归显示，随着PK2升高，肥胖的优势比显著升高。