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炔烃与醛的区域选择性还原偶联反应生成烯丙醇。

Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols.

作者信息

Takai Kazuhiko, Sakamoto Shuji, Isshiki Takahiko

机构信息

Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima, Okayama 700-8530, Japan.

出版信息

Org Lett. 2003 Mar 6;5(5):653-5. doi: 10.1021/ol0272996.

DOI:10.1021/ol0272996
PMID:12605482
Abstract

Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl(2) and a catalytic amount of NiCl(2) and triphenylphosphine in the presence of water in DMF at 25 degrees C gives a 1,2-disubstituted allylic alcohol regioselectively.

摘要

在25℃下，于N,N-二甲基甲酰胺（DMF）中，在水存在的情况下，用二氯化铬（CrCl₂）以及催化量的二氯化镍（NiCl₂）和三苯基膦处理末端炔烃和醛的混合物，可区域选择性地得到1,2-二取代烯丙醇。

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