Bayliss C E, Crawford F B, Nsafoah B
Can J Surg. 1976 Mar;19(2):117-22.
Use of a new isometric rabbit-heart model, a modification of Langer's original preparation, has permitted independent assessment of myocardial perfusability in addition to contractility and relaxation. In this model an isolated, paced, interventricular septum contracts against a tension transducer and is perfused from another awake rabbit. Heparinized, diluted arterial blood is warmed and pumped at 1 ml/g-min. Perfusion pressure is measured by transducer. Each preparation serves as its own control. This model was used in determining performance norms for 68 preparations. Contractility was measured by maximum active tension, maximum rate of increase of tension and time to peak tension; relaxation by resting tension, maximum rate of relaxation and relaxation time; and perfusability by mean perfusion pressure and mean conductance. The status of the parabiotic rabbit was closely monitored. These studies have shown that the model is relatively simple, clearly defined and adaptable to a variety of experimental protocols.
使用一种新的等长兔心模型（对兰格原始制备方法的一种改进），除了收缩性和舒张功能外，还能够独立评估心肌灌注能力。在该模型中，一个孤立的、有起搏功能的室间隔对着张力传感器收缩，并由另一只清醒的兔子进行灌注。肝素化的稀释动脉血被加热并以1毫升/克·分钟的速度泵入。灌注压力由传感器测量。每个制备物自身作为对照。该模型用于确定68个制备物的性能标准。收缩性通过最大主动张力、张力最大上升速率和达到峰值张力的时间来测量；舒张功能通过静息张力、最大舒张速率和舒张时间来测量；灌注能力通过平均灌注压力和平均传导率来测量。联体兔的状态受到密切监测。这些研究表明，该模型相对简单、定义明确，并且适用于各种实验方案。
