Berleur M-P, Dahan A, Murat I, Hazebroucq G
Agence générale des équipements et produits de santé, Etablissement pharmaceutique des hôpitaux de Paris, UF Affaires réglementaries, Paris, France.
J Clin Pharm Ther. 2003 Feb;28(1):31-40. doi: 10.1046/j.1365-2710.2003.00456.x.
To assess the usefulness of Ringer-lactate solution with 0.9% dextrose, fluid therapy during surgery in paediatric patients was reviewed. From the literature, the need for intravenous (i.v.) infusion and water could be established. The need for sodium was also evident and use of normonatraemic i.v. solutions should be recommended to avoid hyponatraemia. Little data were found about the value of the other electrolytes. Dextrose requirements have been the subject of debate for the last two decades. The choice of dextrose concentration is a compromise between avoiding hypoglycaemia and hyperglycaemia. Four clinical trials assessing the use of Ringer-lactate solution with 0.9 or 1% dextrose in paediatric patients suggest that it is appropriate for routine infusion in paediatric patients during the perioperative period. However, fluid therapy during surgery has rarely been studied, probably because it is inexpensive, rarely leads to problems and is used in very different clinical settings. Development of consensus clinical guidelines on the use of electrolyte infusions in paediatric surgery would be helpful.
为评估含0.9%葡萄糖的乳酸林格氏液在小儿患者手术期间液体治疗中的作用,对相关文献进行了回顾。从文献中可以确定静脉输注和水分的需求。钠的需求也很明显,应推荐使用等渗静脉溶液以避免低钠血症。关于其他电解质的价值,几乎没有相关数据。在过去二十年中,葡萄糖需求一直是争论的焦点。葡萄糖浓度的选择是避免低血糖和高血糖之间的折衷。四项评估含0.9%或1%葡萄糖的乳酸林格氏液在小儿患者中应用的临床试验表明,它适用于小儿患者围手术期的常规输注。然而,手术期间的液体治疗很少被研究,可能是因为它价格低廉,很少导致问题,并且在非常不同的临床环境中使用。制定小儿外科电解质输注使用的共识临床指南将有所帮助。