Velagaleti Gopalrao V N, Tapper Jill K, Panova Neli E, Miettinen Markku, Gatalica Zoran
Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Cancer Genet Cytogenet. 2003 Mar;141(2):160-3. doi: 10.1016/s0165-4608(02)00725-2.
We report a case of nodular fasciitis with a reciprocal translocation involving both homologues of chromosome 15 [46,XX,t(15;15)(q13;q25)]. This is the third case of nodular fasciitis with involvement of chromosome 15. Two genes that are involved in either wound healing and/or tumorigenesis have been mapped to chromosome 15. One of the genes, the keratinocyte growth factor or fibroblast growth factor 7 (KGF or FGF7) was mapped to the 15q22 region, which was involved in a cytogenetic rearrangement in one case of nodular fasciitis. KGF is implicated in wound healing, healing lung injuries and tumorigenesis of various cancers such as breast and prostate. The second gene involved is TRKC or NTRK3 mapped to the 15q25 region. TRKC is implicated in congenital fibrosarcoma, a benign proliferation of fibroblasts. The breakpoint and overexpression of the protein in our case further suggest a possible involvement of TRKC.
我们报告了一例伴有涉及15号染色体两条同源染色体的相互易位的结节性筋膜炎病例[46,XX,t(15;15)(q13;q25)]。这是第三例涉及15号染色体的结节性筋膜炎病例。两个与伤口愈合和/或肿瘤发生相关的基因已被定位到15号染色体。其中一个基因，即角质形成细胞生长因子或成纤维细胞生长因子7（KGF或FGF7）被定位到15q22区域，在一例结节性筋膜炎中该区域发生了细胞遗传学重排。KGF与伤口愈合、肺损伤修复以及乳腺癌和前列腺癌等多种癌症的肿瘤发生有关。另一个相关基因是TRKC或NTRK3，定位于15q25区域。TRKC与先天性纤维肉瘤有关，后者是成纤维细胞的良性增殖。我们病例中该蛋白的断点和过表达进一步提示TRKC可能参与其中。
