Petito C K, DeGirolami U, Earle K M
Cancer. 1976 Apr;37(4):1944-52. doi: 10.1002/1097-0142(197604)37:4<1944::aid-cncr2820370446>3.0.co;2-#.
Two hundred and forty-five cases of craniopharyngiomas were obtained from the files of the AFIP and reviewed statistically with reference to their gross and microscopic appearance and clinical data. The majority of the tumors were cystic and microscopically, cysts were formed by squamous epithelial maturation, by degeneration of the stellate cells at the centers of adamantinomatous nests, or by degeneration of the stroma. Transitional forms were seen between adamantinomatous and squamous epithelium and keratohyaline granules and keratin were present in some cases. Because of this overlap, differentiation between craniopharyngiomas and suprasellar epidermoid cysts often is not possible. Significantly increased acturial survival rates were associated with absence of calcification in plain skull films in adults, negative CSF examination, and tumor size under 3.0 cm.
从武装部队病理研究所（AFIP）的档案中获取了245例颅咽管瘤病例，并根据其大体和显微镜下表现以及临床数据进行了统计学回顾。大多数肿瘤为囊性，在显微镜下，囊肿由鳞状上皮成熟、成釉细胞瘤巢中心的星状细胞退变或间质退变形成。在成釉细胞瘤和鳞状上皮之间可见过渡形式，部分病例中存在透明角质颗粒和角蛋白。由于这种重叠，颅咽管瘤与鞍上表皮样囊肿之间的鉴别往往是不可能的。成人平片无钙化、脑脊液检查阴性以及肿瘤大小小于3.0 cm与实际生存率显著提高相关。
