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1
Chalone-like effect abrogated by dextran sulphate and heparin polyanion pretreatment of target cells.硫酸葡聚糖和肝素多阴离子预处理靶细胞可消除类抑素样效应。
Br J Cancer. 1975 Jun;31(6):649-52. doi: 10.1038/bjc.1975.111.
2
Influence of DEAE-dextran, polybrene, dextran and dextran sulphate on spontaneous leukaemia development in AKR mice and virus induced leukaemia in BALB-c mice.二乙氨基乙基葡聚糖、聚凝胺、葡聚糖和硫酸葡聚糖对AKR小鼠自发性白血病发生及BALB - c小鼠病毒诱导白血病的影响。
Br J Cancer. 1974 Jul;30(1):68-72. doi: 10.1038/bjc.1974.114.
3
Arrest of cell membrane movements by in vitro incubation with polycation reversed by polyanion.
J Cell Sci. 1979 Jun;37:181-7. doi: 10.1242/jcs.37.1.181.
4
Effects of heparin and dextran sulphate on the production of collagen and protein in diabetic and non-diabetic human skin fibroblast cultures.肝素和硫酸葡聚糖对糖尿病和非糖尿病人体皮肤成纤维细胞培养物中胶原蛋白和蛋白质产生的影响。
Med Biol. 1983 Jun;61(3):186-90.
5
The hepatic chalone. II. Chemical and biological properties of the rabbit liver chalone.肝抑素。II. 兔肝抑素的化学和生物学特性。
Biomedicine. 1975 May;22(3):195-208.
6
DEAE-dextran and polybrene cation inhibition of antibody/complement mediated in vitro immune haemolysis.
Scand J Haematol. 1976 Apr;16(4):271-8. doi: 10.1111/j.1600-0609.1976.tb01150.x.
7
Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. II. Relationship between adjuvant activity and stimulation of DNA synthesis by polyanions.体外多聚阴离子对小鼠淋巴细胞DNA合成的刺激作用。II. 佐剂活性与多聚阴离子对DNA合成刺激作用之间的关系。
Eur J Immunol. 1973 Aug;3(8):493-6. doi: 10.1002/eji.1830030808.
8
Inhibition of granulopoiesis in diffusion chambers by a granulocyte chalone.粒细胞抑素对扩散盒中粒细胞生成的抑制作用。
Exp Hematol. 1974;2(4):182-94. doi: 10.21236/ada004595.
9
A lymphocyte-inhibiting factor (chalone?) extracted from thymus: immunosuppressive effects.从胸腺中提取的一种淋巴细胞抑制因子（抑素？）：免疫抑制作用。
Natl Cancer Inst Monogr. 1973 Jul;38:135-42.
10
Derivatized dextran inhibition of smooth muscle cell proliferation.
J Biomater Sci Polym Ed. 1991;3(2):149-54. doi: 10.1163/156856291x00241.

本文引用的文献

1
Enhancement of the plaque-forming capacity of poliovirus ribonucleic acid with basic proteins.碱性蛋白对脊髓灰质炎病毒核糖核酸噬斑形成能力的增强作用。
J Bacteriol. 1962 Nov;84(5):1035-40. doi: 10.1128/jb.84.5.1035-1040.1962.
2
Action of polylysine on some ascites tumors in mice.聚赖氨酸对小鼠某些腹水瘤的作用。
Proc Soc Exp Biol Med. 1959 Jun;101(2):382-6. doi: 10.3181/00379727-101-24950.
3
A model of growth and growth control in mathematical terms.一个用数学术语描述的生长及生长控制模型。
J Gen Physiol. 1957 Sep 20;41(1):1-47. doi: 10.1085/jgp.41.1.1.
4
Cell electrophoretic mobilities in Friend virus disease.弗瑞德病毒病中的细胞电泳迁移率
Nature. 1967 Jul 15;215(5098):279-80. doi: 10.1038/215279a0.
5
A rapid method for quantitation of the incorporation of 3H-thymidine by lymphocytes in vitro.一种体外定量淋巴细胞掺入³H-胸腺嘧啶核苷的快速方法。
Acta Pathol Microbiol Scand. 1969;75(3):508-11.
6
Inhibitory effect of polycations on the transplantability of mouse leukaemia reversed by heparin.多阳离子对小鼠白血病移植性的抑制作用被肝素逆转。
Eur J Cancer (1965). 1968 May;4(2):157-62. doi: 10.1016/0014-2964(68)90013-3.
7
Lymphocyte DNA synthesis inhibition.淋巴细胞DNA合成抑制。
Science. 1971 Sep 17;173(4002):1139-41. doi: 10.1126/science.173.4002.1139.
8
Standardized nomenclature for inbred strains of mice: fifth listing.小鼠近交系标准化命名法：第五版名录
Cancer Res. 1972 Aug;32(8):1609-46.
9
Delayed inhibition of epidermal DNA synthesis after injection of an aqueous skin extract (chalone).注射皮肤水提取物（抑素）后表皮DNA合成的延迟抑制
Virchows Arch B Cell Pathol. 1969;4(1):45-53. doi: 10.1007/BF02906060.
10
Influence of DEAE-dextran, polybrene, dextran and dextran sulphate on spontaneous leukaemia development in AKR mice and virus induced leukaemia in BALB-c mice.二乙氨基乙基葡聚糖、聚凝胺、葡聚糖和硫酸葡聚糖对AKR小鼠自发性白血病发生及BALB - c小鼠病毒诱导白血病的影响。
Br J Cancer. 1974 Jul;30(1):68-72. doi: 10.1038/bjc.1974.114.

硫酸葡聚糖和肝素多阴离子预处理靶细胞可消除类抑素样效应。

Chalone-like effect abrogated by dextran sulphate and heparin polyanion pretreatment of target cells.

作者信息

Ebbesen P, Olsson L

出版信息

Br J Cancer. 1975 Jun;31(6):649-52. doi: 10.1038/bjc.1975.111.

DOI:10.1038/bjc.1975.111
PMID:126071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009467/
Abstract

Chalone prepared from primary BALB/c mouse embryo fibroblasts caused a 33% reduction in incorporation of tritiated thymidine in the cultures of the second in vitro passage of BALB/c embryo fibroblasts, whereas chalone prepared from thymus, skin and spleen was without effect. Pretreatment of BALB/c secondary fibroblasts with the polyanions dextran sulphate and heparin abrogated the chalone effect. The polycations DEAE-dextran and polybrene were without effect. The effect of incubation with the dextran sulphate polyanion was reversed when followed by incubation with DEAE-dextran polycation.

摘要

从原代BALB/c小鼠胚胎成纤维细胞制备的抑素，使BALB/c胚胎成纤维细胞体外传代培养第二代的氚标记胸腺嘧啶核苷掺入量减少了33%，而从胸腺、皮肤和脾脏制备的抑素则无此作用。用聚阴离子硫酸葡聚糖和肝素对BALB/c二代成纤维细胞进行预处理可消除抑素的作用。聚阳离子二乙氨基乙基葡聚糖和聚凝胺则无此作用。在用硫酸葡聚糖聚阴离子孵育后再用二乙氨基乙基葡聚糖聚阳离子孵育，其作用可逆转。