Hojaij C R
Melbourne Clinic, 130 Church Street, Richmond, Victoria, 3121, Australia.
World J Biol Psychiatry. 2000 Jan;1(1):43-54. doi: 10.3109/15622970009150565.
One century of investigation in schizophrenia is still not enough to elucidate all the complex issues related to the essential symptomatology, clinical boundaries, aetiology, pathogenesis, outcome, treatment and prevention. Despite the extraordinary progress in the neuroscience field, no definitive data is available for schizophrenia. On the other hand, after the successful activity of the psychopharmacological era, the clinical psychopathological investigations were reduced and almost replaced by the mechanistic operational diagnosis. This has caused an impoverishment in psychiatry. Tracing some historical aspects of schizophrenia since the kraepelinian Dementia Praecox, this article intends to demonstrate the failure of the current model of diagnosis and current limitation of neuroscience. It advocates the reinforcement of Clinical Psychopathology as the foundation for correct and appropriate first steps in the investigation of schizophrenia. The splitting disease is still a challenge to biological psychiatry.
一个世纪以来对精神分裂症的研究仍不足以阐明所有与基本症状学、临床界限、病因、发病机制、转归、治疗及预防相关的复杂问题。尽管神经科学领域取得了非凡进展，但对于精神分裂症仍没有确凿的数据。另一方面，在精神药理学时代取得成功之后，临床精神病理学研究减少，几乎被机械的操作性诊断所取代。这导致了精神病学的贫瘠。追溯自克雷佩林的早发性痴呆以来精神分裂症的一些历史方面，本文旨在论证当前诊断模式的失败以及神经科学目前的局限性。它主张强化临床精神病理学，将其作为精神分裂症研究正确且恰当的首要步骤的基础。这种分裂性疾病对生物精神病学而言仍是一项挑战。
