Ma Furong, Li Xuepei, Zhao Yimin, Zhong Zhen, Gu Yalan, Yan Jinhua
Department of Otolaryngology, Third Hospital of Beijing University, Beijing 100083.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Apr;16(4):174-6.
To study effect of nimodipine (ND) on cochlear blood flow (CBF).
CBF was measured in twenty-two guinea pigs by laser Doppler flowmetry(LDF).
Nimodipine decreased CBF following the decrease of systemic BP and present a dose dependent mode, neither the dose of nimodipine is lower, normal and higher, nor the animal is under the status of normal supply of inner ear blood flow and ischemia of inner ear caused by vertebrobasilar insufficiency(VBI).
It suggested that this compound may be of little clinical use to elevate CBF.
研究尼莫地平（ND）对耳蜗血流量（CBF）的影响。
采用激光多普勒血流仪（LDF）测量22只豚鼠的CBF。
尼莫地平随全身血压降低而使CBF下降，并呈剂量依赖性，无论尼莫地平剂量低、正常或高，也无论动物处于内耳血流正常供应状态还是椎基底动脉供血不足（VBI）所致内耳缺血状态。
提示该化合物对提高CBF可能临床应用价值不大。
