Coleman J K, Dengerink H A, Wright J W
Department of Psychology, Washington State University, Pullman 99164-4820.
Otolaryngol Head Neck Surg. 1991 Dec;105(6):840-4. doi: 10.1177/019459989110500612.
A primary goal of pharmacologic treatment for otopathologies of vascular origin is to elevate cochlear blood flow (CoBF), thus facilitating the transport of oxygen and nutrients without compromising perfusion pressure in other tissues. In the present investigation, significant increases in CoBF were measured during intra-arterial infusion of the plasma expanding agent, hydroxyethyline starch (HES), and the vasodilator nimodipine, in anesthetized adult male guinea pigs. There were no changes in systemic blood pressure during the infusion of HES or nimodipine. Intra-arterial infusion of propylene glycol (PG), which is used as a nonaqueous solvent, produced inconsistent CoBF effects accompanied by initial decreases in systemic blood pressure with subsequent increases. It is concluded that nimodipine and HES are very promising agents for inducing increases in CoBF, whereas PG produced inconsistent effects on CoBF while elevating blood pressure, thus compromising its potential usefulness in the treatment of otopathologies.
血管源性耳病药理学治疗的主要目标是提高耳蜗血流量（CoBF），从而促进氧气和营养物质的输送，同时不影响其他组织的灌注压力。在本研究中，在麻醉的成年雄性豚鼠动脉内输注血浆扩容剂羟乙基淀粉（HES）和血管扩张剂尼莫地平时，测量到CoBF显著增加。输注HES或尼莫地平时，全身血压无变化。动脉内输注用作非水溶剂的丙二醇（PG）产生的CoBF效应不一致，同时伴有全身血压先降低后升高。结论是，尼莫地平和HES是诱导CoBF增加的非常有前景的药物，而PG对CoBF产生不一致的影响，同时升高血压，从而损害了其在耳病治疗中的潜在用途。
