Haug H, Kölln M, Rast A
Cell Tissue Res. 1976 Mar 16;167(2):265-88. doi: 10.1007/BF00224332.
With the aid of stereological procedures the development of myelinated nerve fibres (MF) was quantitatively investigated in electron micrographs of the visual cortex from animals of different ages: 36 days-old, the age at which fibres first appear, through adulthood. A short description of tissue treatment, methods and qualitative results is given. The following quantitative results are presented: 1. Myelinization begins at about the 36th day postpartum and is not completed by the 164th day. At this time a lack of about 20% MF can be observed. 2. The average diameter of MF decreases from 1.3 mum to 0.8 mum from day 36 to adulthood. 3. The first MF appear near the border of the album. 4. Beginning with the 55th day, small MF arise in layer I, showing two periods of growth. 5. The maximum MF density in the region of layer IV corresponds to the strip of Baillarger. Other aspects of visual cortex development are dealt with in the Discussion. The following conclusions can be drawn: a) The growing of in- and output-MF is completed first. b) The development of the internal connecting systems in layers I and IV begins a little later and is completed by the 5th month. c) The MF in layers II and III appear after the 4th month. Kaes (1907) has also described a continuation of MF growth in man lasting into the twenties.
借助体视学方法，对不同年龄（从纤维首次出现的36日龄到成年）动物视觉皮层的电子显微照片中髓鞘神经纤维（MF）的发育进行了定量研究。给出了组织处理、方法和定性结果的简要描述。呈现了以下定量结果：1. 髓鞘形成始于产后约第36天，到第164天时尚未完成。此时可观察到约20%的MF缺失。2. 从第36天到成年，MF的平均直径从1.3μm减小到0.8μm。3. 第一批MF出现在白质边缘附近。4. 从第55天开始，I层出现小的MF，呈现两个生长阶段。5. IV层区域的最大MF密度对应于贝亚尔热带。视觉皮层发育的其他方面在讨论中涉及。可以得出以下结论：a）传入和传出MF的生长首先完成。b）I层和IV层内部连接系统的发育稍晚开始，到第5个月完成。c）II层和III层的MF在第4个月后出现。凯斯（1907年）也描述了人类MF生长持续到二十多岁。
