双层酰胺E-J，源自菲律宾海鞘双纹扁海鞘的修饰环状六肽。

Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum.

作者信息

Perez Lark J, Faulkner D John

机构信息

Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212.

出版信息

J Nat Prod. 2003 Feb;66(2):247-50. doi: 10.1021/np0204601.

DOI:10.1021/np0204601

PMID:12608858

Abstract

The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.

摘要

菲律宾海鞘双纹 Lissoclinum bistratum 含有已知的代谢产物双纹酰胺 C 和 D，以及六种新型修饰的环六肽，即双纹酰胺 E-J。通过光谱数据分析阐明了双纹酰胺 E-J 的结构，并在臭氧分解和酸催化水解后确定了组成氨基酸的绝对立体化学。在 HCT-116 细胞系试验中，双纹酰胺 E-J 具有中等细胞毒性。