Rashid M A, Gustafson K R, Cardellina J H, Boyd M R
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
J Nat Prod. 1995 Apr;58(4):594-7. doi: 10.1021/np50118a020.
Cytotoxicity-directed fractionation of an organic extract of the tunicate Lissoclinum patella afforded a new cyclic octapeptide, patellamide F [1]. The structure and absolute stereochemistry of 1 were established by a combination of spectroscopic and chemical methods. Three known cyclic peptides, patellamide B [2], ulithiacyclamide, and lissoclinamide 3, were also isolated and identified.
对被囊动物扁缩海鞘的有机提取物进行细胞毒性导向分级分离，得到了一种新的环八肽——扁缩海鞘酰胺F [1]。通过光谱和化学方法相结合确定了1的结构和绝对立体化学。还分离并鉴定出了三种已知的环肽——扁缩海鞘酰胺B [2]、硫环酰胺和扁缩海鞘酰胺3。
